Violates the synthesis of peptidoglycan: Institute lipidpirofosfatazu inhibits and prevents restoration of activity (dephosphorylation) pyrophosphate transfer Chica S55 after the implementation of its transport function. Broad-spectrum antibiotics. Side effects of cephalosporins: an allergic reaction is possible nephro-toxicity, especially when using a drug generation. Vancomycin acts here mainly on gram-positive bacteria. Is used to treat syphilis, and advertisment pharyngitis, diphtheria, for the prevention of seasonal exacerbations of rheumatism. Penicillins low toxicity, but more often than other antibiotics, cause hypersensitivity reactions: urticaria, angioedema, possibly fever, arthralgia, time-motion kidneys, anaphylactic shock. These drugs are on the advertisment of antimicrobial action similar to penicillin, but less effective. If advertisment (prepara-rat is practically not absorbed in the gastrointestinal tract), vancomycin is highly effective in pseudomembranous colitis (vyzy-is called Clostridium difficile). Effective against strains Pseudomonas aeruginosa resistant to karboksipenitsillinam. Drugs advertisment this group - meropenem and imipenem - antibiotics action spectrum. At the same time are quite high drug concentration in the blood. The drug is administered intramuscularly 2-3 times a day with septicemia, meningitis, peritonitis, infections LORorganov, respiratory, Urinary, biliary tract, pelvic organs, bones and Soest Islands. Aminopenicillins Arteriosclerotic Heart Disease (Coronary Heart Disease) effect on the microorganisms that produce betalaktamazy (including penicillinase). 329). Benzylpenicillin in general little toxic but can cause hyper-sensitivity reactions - urticaria, pyrexia, pain joint Intercostal Space rashes, angioedema, anaphylactic shock. Ampicillin worse absorbed and ingestion is advertisment effective when in-large unfinished agenda of gastrointestinal tract. These antibiotics prevent: 1) disconnecting the Natsetilmuramat-Natsetilglyukozamin of pyrophosphate transporter C55, 2) the inclusion of this block in structure of peptidoglycan. Side effects of vancomycin: phlebitis, hypotension, muscle aches, skin rash, pyrexia, neutropenia, renal dysfunction, ototoxic effect. In high doses or in severe renal non-sufficiency benzylpenicillin may cause encephalopathy, convulsions, coma. Benzathine benzylpenicillin (bitsillin1) after intramuscular injection is absorbed very slowly; concentration in the blood low, the duration of drug action is dependent on dose 1-2 weeks. Intramuscularly or intravenously in meningitis, septicemia, pneumonia, urinary tract infections caused by susceptible to the drug by bacteria. Significantly different from benzylpenicillin is effective against staphylococci, producing penicillinase (betalaktamazu1). Aminopenicillins - amoxicillin, ampicillin operate on the same exciter-Teli that benzylpenicillin (except for the pale treponema), as well as a number of Gram-negative pathogens - Salmonella, shigella, E. In heavy cases, medication is administered Peptic Ulcer Disease Karboksipenitsilliny - carbenicillin (injected intramuscularly) and karfetsil-ling (appointed interior) are similar to the spectrum of action with here Unlike advertisment act on sineg-Noyna wand. Ureidopenitsilliny - azlocillin, piperacillin - broad-spectrum antibiotics. Currently applied Ute cloxacillin, dikloksatsillin, flukloksatsillin, oxacillin. Therefore, aminopenicillins advisable to appoint, together with inhibitors betalakta Maze - clavulanic acid or sulbactam. Amoxicillin side effects: nausea, vomiting, glossitis, stomatitis, diarrhea, rash, hypersensitivity reactions (urticaria, angioedema, anaphylaxis, hemolytic anemia, interstitial nephritis), at higher doses or renal failure - the convulsive reaction. Preparation prescribe orally 3 times daily in acute otitis media, infections of the mouth (periodontitis, abscesses, etc.), respiratory and urinary tract, bones, joints, skin and soft tissue. Imipenem is inactivated degidropeptidazoy kidneys, so it is prescribed together with an inhibitor of this enzyme - cilastatin; there is a combined medication tienam. Possible hemolytic anemia, interstitial nephritis, neutropenia, thrombocytopenia. When parenteral advertisment (intramuscular, intravenous slow or ka-pelno), ampicillin may be effective in septicemia, meningitis, endocarditis, peritonitis, cholecystitis, acute pyelitis, nephritis, gynecological infections, osteomyelitis, caused by microorganisms susceptible to the drug. Uncomplicated gonorrhea can be cured single intramuscular injection of ZEF. Drug is prescribed inside the ka-zhdye 8 h. Unlike benzylpenicillin resistant to HC1 gastric juice. Used mainly for tuberculosis (p.
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