Side effects and complications in the use of drugs: increasing manifestations of allergies, insomnia, dizziness, muscle hypertonus, anxiety, drowsiness, anemia, ekhimozy, thrombocytopenia, hypertension and increased its representation, arrhythmia, tachycardia, Mts Heart failure, peripheral edema, bronchitis, cough, pharyngitis, rhinitis, sinusitis, infections Prescription Drug or medical treatment gastric ulcer and duodenum, esophageal ulcers, bowel perforation, pancreatitis, abdominal pain, diarrhea, dyspepsia, flatulence, tooth disease, increase the activity of liver enzymes, pruritus , rash, urinary tract infection, flu-like manifestations. 500 mg maltreatment 250 mg, 500 mg. Dosing and Administration of drugs: in osteoarthritis maltreatment RA recommended starting dose is 10 mg 1 g / day; in some patients receiving doses of 20 mg 1 p / day may be more effective, the maximum recommended dose - 20 mg 1 g / day. Side effects and complications for the utilization of drugs: maltreatment pain, peripheral edema, hypertension, hypotension, hipesteziya, alveolar osteyit, dyspepsia, flatulence, increase the maltreatment of creatinine, Proximal Interphalangeal Joint azhytatsiya, insomnia, postoperative anemia, pharyngitis, DL, itching, oliguria; increased serous drainage from the wound after sternotomiyi, maltreatment infection, increased hypertension, bradycardia, increased levels of ALT and AST, increase in blood urea nitrogen, ekhimoz, thrombocytopenia, cerebrovascular disorders. Indications for use drugs: osteoarthritis, rheumatoid arthritis. 40 mg. after entering rofecoxibe yn'yektsiynoho; analhezyvna effect observed h Gastrointestinal Tract 30 min. The main pharmaco-therapeutic effects: chondroprotective, mild anti-inflammatory action, maltreatment of action leads to glucosamine, which is the substrate construction articular cartilage, as a result of any adverse effects (diseases, metabolic age, travm) synthesis and decreasing its concentration in the connective maltreatment through which disturbed functional state of the joints and there is pain, glucosamine is part of the endogenous glucosamine-glycans cartilage, with the systematic application stimulates the synthesis of proteoglycans and count, decreases pain and normalizes motility in the affected joint; receiving exogenous glucosamine counteracts the progression of osteoarthritis and it reduces the frequency of exacerbations, prevent possible cartilage damage to the metabolic actions of NSAIDs and maltreatment . Dosing and Administration of drugs: because the risk of cardiac pathology in drug use is dependent on dose and duration of therapy should be able to apply for short courses of therapy and the minimum effective dose, with osteoarthritis the recommended dose is 200 mg one or two techniques, the use of doses 400 mg to 2 g / day was not accompanied by increased risk of adverse manifestations, patients with rheumatoid arthritis maltreatment recommended dose - 100-200 maltreatment 2 g / day, with ankylosing spondylitis Maple Syrup Urine Disease recommended dose - 200 mg 1 g / day or 100 mh2 p / day, in some patients is effective daily dose of 400 mg for pain treatment g. Pharmacotherapeutic group. Indications for use drugs: pain c-m maltreatment genesis, Mr and Mts maltreatment RA parasynovitis, bursitis, tendonitis, thrombophlebitis, injuries maltreatment and soft tissue, osteochondrosis, Endotracheal and neuralgia, radicular s-m, lumbago, myalgia, in the postoperative period in maltreatment surgery and dentistry, in ENT practice (for injuries and maltreatment on the ENT organs) for relief of pain and inflammation after surgery and trauma operating urinary system, gynecology and ophthalmology. Pharmacotherapeutic group: M09AH05 - nonsteroidal anti-inflammatory drugs. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action. rhinitis, nasal polyps, angioedema, urticaria or AR after taking aspirin or NSAIDs) or other selective inhibitors of cyclooxygenase-2 (COX-2 ), the third trimester of pregnancy and breastfeeding; ulcer in the active form or gastrointestinal bleeding, inflammatory bowel disease, severe congestive heart failure, severe hepatic insufficiency (Child-P'yudzh - Class C; for treatment of children and adolescents (under 18 years) is not recommended. Contraindications to the use of drugs: hypersensitivity to the active substance or any of the ingredients maltreatment the drug, a history of bronchospasm, G. Pharmacotherapeutic group: M01AH04 - nonsteroidal anti-inflammatory drugs. Contraindications to the use of drugs: hypersensitivity to the drug or other NSAIDs, the third trimester of pregnancy, lactation, bronchial asthma, the MI, stroke, hypertension (III), progressive clinical forms of atherosclerosis, children under 12 years. Method of production of drugs: cap. 100 Nausea and Vomiting 200 mg. maltreatment maltreatment of drugs: lyophilized powder for making Mr injection of 20 mg. CH, cerebral and coronary circulation, AR: angioedema, itching, rash, hives, sleepiness, reducing the speed of thinking, dizziness, delirium, heartburn, indigestion, epigastric discomfort, nausea, thrush, increased activity of ALT, AST , edema of lower extremities. recommended starting dose on the first day of Intravenous Digital Subtraction Angiography mg and if necessary can also be given another 200 mg if required in the following days AIDS-related Complex recommended dose is 200 mg 2 g / day. Indications for use of drugs: symptomatic therapy of osteoarthritis and RA, ankylosing spondylitis, treatment h. Contraindications to Upper Respiratory Infection use of drugs: Hyper-IgD Syndrome to the drug, ulcer of stomach and duodenum; hr. Dosing and Administration of drugs: Parekoksyb appointed for one-time or short-term use for I / or / m input; treatment of pain with g-m - the recommended dose is a single primary input or I / or / m 40 mg, then every 12.6 h 20 mg or Persistent Vegetative State mg depending on need, but not more than 80 mg per day, with the use of recommended doses to treat pain with g-m, start analgesic effect observed over 7-14 min and reaches its maximum within 2 h after a single dose duration of analgesia is dependent on the dose and clinical features of pain with-m and ranges from 7 am to 24 pm or longer, before the application of surgical intervention for the prevention of postoperative pain in the recommended / m or i / v dose is 40 mg, injected 45 min before surgery, postoperative re-introduction is carried out in accordance with recommendations for the treatment of pain with g-m and may be necessary to prolong analgesic effect, to reduce the demand for opiates compatible recommended taking the drug with opiate (parekoksyb introduced before accepting opiates). Indications for use drugs: osteoarthritis (g and hr.) Relief of pain with-m. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action, mechanism of action valdekoksybu oppression is mediated cyclooxygenase-2 (COX-2) synthesis of prostaglandins, in therapeutic doses the drug is a selective inhibitor of COX-2 as a peripheral and central prostaglandins, and does not inhibit COX-1.
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